Cytosporone B

Research use only, not for human use.

Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).

Cytosporone B is the first naturally occurring agonist for nuclear orphan receptor Nur77. The molecule binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is also involved in glucose homeostasis, where it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.

Cytosporone B; Cytosporone-B; Csn-B; Dothiorelone G

GPCR/G Protein

Antibacterial

Nur77

——

——

321661-62-5

322.4

C18H26O5

96%

DMSO : ≥ 100 mg/mL; 310.17 mM

CCCCCCCC(=O)c1c(cc(cc1CC(=O)OCC)O)O

Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate

(-20℃)

With Ice Pack

≥ 2 years